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The tenth installment in the World Trade Center (WTC) Health Program’s Clinical Best Practices Webinar series explained the addictive characteristics of nicotine and smoking and describe effective treatment strategies. This one-hour training can count towards the eight hours of training on substance use disorders that is newly required for all Drug Enforcement Administration (DEA)-registered practitioners. This requirement was enacted on December 29, 2022 in the Consolidated Appropriations Act of 2023. Cigarette smoking is the leading cause of preventable disease, disability, and death in the United States. The U.S. Preventive Services Task Force (USPSTF) recommends that smoking cessation services be offered to all adults who currently smoke. Effective treatment includes behavioral counseling and FDA-approved pharmacological treatments; however, combination therapy (i.e., medications and behavioral counseling) are known to be most effective. This webinar was delivered by Geoffrey M. Calvert, MD, MPH, FACP and Sandra M. Lowe, MD. Webinars in the Best Practices for Clinical Care series are recorded and generally available within 4 weeks after the live session. You can view past webinar recordings in the Previous Webinars section. Free Continuing Education Credits are available.