Gastroenterology | Drugs for Viral Hepatitis & Cirrhosis скачать в хорошем качестве

Gastroenterology | Drugs for Viral Hepatitis & Cirrhosis

🍐 In this episode of PodBites, Jana Khalifa and Sabin Fadlalla guide you through the pharmacologic management of viral hepatitis and cirrhosis — from shutting down viral replication to managing life-threatening complications of end-stage liver disease — using molecular mechanisms, clinical reasoning, and high-yield treatment principles. 🎙️ Tune in to explore: • The pathophysiology of chronic hepatitis B and C, and how persistent infection leads to cirrhosis and cancer • First-line treatments for hepatitis B, including Tenofovir, Entecavir, and Pegylated Interferon, and how they block viral replication • The mechanism and clinical role of nucleoside and nucleotide analogues, including chain termination of viral DNA • Modern direct-acting antivirals (DAAs) for hepatitis C, including -previr, -asvir, and -uvir drugs, and their targeted mechanisms • Ribavirin’s mechanism, role in combination therapy, and its critical adverse effect of hemolytic anemia • The pathophysiology of cirrhosis, including fibrosis, portal hypertension, and progressive liver dysfunction • Management of cirrhosis complications, including beta-blockers for portal hypertension, diuretics for ascites, and lactulose and rifaximin for hepatic encephalopathy • Emerging therapies like Resmetirom, targeting fibrosis and disease progression 🌟 A structured, high-yield guide to understanding antiviral therapy and cirrhosis management, helping you connect molecular pharmacology to real clinical outcomes with confidence.