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Professor Payne and Dr Luis Martinez-Piñeiro discuss the key topics presented at the 13th Prostate Cancer Debate in Madrid, with a focus on metastatic castration resistant prostate cancer (mCRPC). They talk around the available therapy options and the sequencing of treatment for this group of patients, sharing their opinions on rechallenging and the tolerability of the available therapy options. They also discuss the St Gallen Consensus and their interest in the variability of practice for treating patients with CRPC around the world. Professor Payne and Dr Martinez-Piñeiro also discuss the treatment of geriatric patients and share views on the idea that treatment decisions should be more focused on co-morbidities than age. Sign up to ecancer for free to receive tailored email alerts for more videos like this. ecancer.org/account/register.php