Semi-Synthetic Cannabinoids: An Emerging NPS Overview and Case Study on In-Vitro Metabolism скачать в хорошем качестве

Semi-Synthetic Cannabinoids: An Emerging NPS Overview and Case Study on In-Vitro Metabolism

Semi-synthetic cannabinoids (SSCs) represent an emerging class of Novel Psychoactive Substances (NPSs) that are often advertised and sold as legal. SSCs can be described as partially synthetic materials that are derived from natural components of the Cannabis Sativa L. plant, such as Cannabidiol (CBD). New studies on the in-vivo and in-vitro metabolism of SSC’s, such as D10-THC, D6a,10a-THC, and HHC, are emerging, which detail the similarities and differences seen to natural phytocannabinoid like D9-THC. Alicyn Stothard and Jonathon Bassman, synthetic organic chemists at Cayman Chemical, discuss the overall landscape of newly emerging SSCs and their metabolism, along with a case study utilizing LC/MS-based identification of putative in-vitro metabolites for the SSC’s Δ10-THC and Δ6a,10a-THC. Presented as part of the CFSRE's 2025 Current Trends in Forensic Toxicology Symposium.