Synthesis Workshop: Asymmetric Hydrogenation of Oximes with Dr. Josep Mas-Roselló (Episode 23) скачать в хорошем качестве

Synthesis Workshop: Asymmetric Hydrogenation of Oximes with Dr. Josep Mas-Roselló (Episode 23)

In this Research Spotlight episode, Dr. Josep Mas-Roselló joins us to talk about his recently published work on the asymmetric hydrogenation of oximes in the Cramer group. Parent reference: Science 2020, 368, 1098-1102. Other references (in order of appearance): ‘The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids’ John Wiley & Sons, Ltd. 2008; ‘The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids’ John Wiley & Sons, Ltd. 2008; ‘The market of chiral drugs’ J. Pharmaceut. Biomed. 2018, 323; ‘Asymmetric homogeneous hydrogenations at scale’ Chem. Soc. Rev. 2012, 3340. ‘Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines’ Chem. Rev. 2011, 1713. ‘Outer sphere hydrogenation catalysis’, O. Eisenstein, R. H. Crabtree, New J. Chem. 2013, 21. For a review on chiral cyclopentadienyl ligands (CpX) in catalysis, see: Angew. Chem. Int. Ed. 10.1002/anie.202008166. ‘Enantioselective oxime hydrogenation process’ T. Smejkal, N. Cramer, J. Mas-Roselló, WO 2020/09452S A1. Work also patented, see: WO 2020/09452S A1.