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For this UCSF Medicine Grand Rounds, our special guest is Dr. Robert Califf, the 25th commissioner of the U.S. Food and Drug Administration (FDA) and a graduate of the UCSF Medicine Residency. We begin by discussing Covid issues, including the bivalent vaccine and the struggles in combating misinformation. We then shift to a wide array of other issues, including balancing cost and efficacy in FDA decision-making, the challenges of regulating medicines for serious illnesses like dementia, creating a regulatory framework for artificial intelligence, and more. Speaker: Robert M. Califf, MD, was confirmed last year as the 25th Commissioner of the U.S. Food and Drug Administration. He also served in 2016-17 as the 22nd Commissioner, and immediately prior to that as the FDA’s Deputy Commissioner for Medical Products and Tobacco. He has spent a good portion of his career affiliated with Duke University, where he was a professor of medicine and vice chancellor for clinical and translational research, director of the Duke Translational Medicine Institute, and the founding director of the Duke Clinical Research Institute. He has had a long and distinguished career as a physician, researcher, and leader in the fields of science and medicine. He is a nationally recognized expert in cardiovascular medicine, health outcomes research, health care quality, and clinical research, and a leader in the growing field of translational research, which is key to ensuring that advances in science translate into medical care. Note: Closed captions will be available within 48-72 hours after posting. Program Bob Wachter: Introduction 00:01:43-01:00:35 – Robert Califf, MD, commissioner, U.S. Food and Drug Administration See previous Medical Grand Rounds: • March 30: Progress in Obstructive Lung Disease: Bedside to Bench and Back • Progress in Obstructive Lung Disease: Beds... • March 23: Clinical Problem Solving • Clinical Problem Solving • March 16: Innovations and Controversy: Updates in Geriatrics • Innovations and Controversy: Updates in Ge... • March 9: Stroke 2023: A Change Has Come and Is Still Coming • Stroke 2023: A Change Has Come and Is Stil... See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, at • UCSF Department of Medicine Medical Grand ... .