Myxopapillary Myxoid and papillary foci Histology of Ependymoma скачать в хорошем качестве

Myxopapillary Myxoid and papillary foci Histology of Ependymoma

Myxopapillary ependymoma is a distinct histological subtype of ependymoma, classified as a WHO Grade II glial tumor, most commonly found in the conus medullaris, cauda equina, and filum terminale of the spinal cord. Its name reflects its characteristic myxoid (gelatinous) stroma and papillary architecture, which are key features under the microscope. 🔬 Histological Features 1. Papillary Architecture Tumor cells are arranged in radial patterns around vascular cores, forming papillary structures. These resemble perivascular pseudorosettes, a hallmark of ependymal tumors. The cells lining the papillae are typically cuboidal to columnar, with round to oval nuclei. 2. Myxoid Background The stroma between the papillary structures contains abundant myxoid material, rich in mucopolysaccharides. This Alcian blue–positive matrix gives the tumor a gelatinous consistency. Microcyst formation may be present within the myxoid zones2. 3. Cellular Characteristics Tumor cells may be spindled or epithelioid, with moderate cellularity. Mitotic figures are rare, and necrosis is typically absent. GFAP positivity confirms glial origin. 🧠 Diagnostic Clues The combination of papillary structures, myxoid stroma, and ependymal cell lining is diagnostic. These tumors are often slow-growing, but can cause significant neurological symptoms due to their location. MRI typically shows a well-defined, enhancing mass in the spinal canal. #myxoid