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Discover 5 risky over-the-counter medication combinations you should never take together, explained simply by a pharmacist. Learn about risky interactions like ibuprofen with aspirin (stomach bleeding), Tylenol (acetaminophen) with alcohol (liver damage), decongestants with blood pressure meds (BP spikes), doubling antihistamines (excessive sedation), and St. John's Wort with other drugs (reduced effectiveness). Get practical tips on uses, common side effects, and precautions to stay safe with OTC meds. Perfect for anyone managing everyday health at home! This video is for educational purposes only, not medical advice or diagnosis. Always consult your healthcare provider before making health decisions. Keywords: OTC medication interactions, dangerous drug combinations, ibuprofen aspirin risk, acetaminophen alcohol liver damage, decongestants high blood pressure Sources used: U.S. Food and Drug Administration: https://www.fda.gov/drugs/resources-d... National Institutes of Health/MedlinePlus (Ibuprofen): https://medlineplus.gov/druginfo/meds... National Institutes of Health/MedlinePlus (Acetaminophen): https://medlineplus.gov/druginfo/meds... Centers for Disease Control and Prevention (related alcohol and drug risks, cross-referenced via NIH sources) World Health Organization (St. John's Wort interactions, via related PubMed/PMC summaries) National Library of Medicine/PubMed Central: https://pmc.ncbi.nlm.nih.gov/articles... (St. John's Wort clinical relevance) StatPearls (general drug interaction principles, aligned with sources)