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In this 15-minute discussion, a panel of experts explores the complexities of pelvic lymph node dissection (PLND) in managing high-risk prostate cancer. The discussion emphasizes that while good surgery and radiation are foundational, lymph node dissection strategies remain crucial in certain scenarios. PET imaging has significantly influenced decision-making. While extended dissection roughly doubles the number of nodes retrieved compared to standard approaches, its therapeutic benefit remains uncertain. Radiation oncologists highlight the importance of boosting radiation doses to areas of suspected nodal involvement, aiming to balance efficacy while protecting critical structures like the bowel and rectum. The surgical experts also emphasize the practical challenges of lymph node dissection, including the variability in dissection boundaries and the occasional difficulty of identifying small, PET-positive nodes that may be undetectable on CT. The panel asserts that while PLND remains an important diagnostic tool with prognostic value, its therapeutic role is limited. Future advancements in PET imaging, biomarkers, and precision radiation techniques are expected to refine patient selection and improve outcomes in high-risk prostate cancer management. Don't forget to join the GRU Community: https://grandroundsinurology.com/regi... Follow us on Twitter/X: https://x.com/GRUrology And like and subscribe to us here on YouTube!