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Extracellular vesicles (EVs) are small, membrane‐enclosed compartments that mediate the transport of proteins and small RNAs between cells. In plants, EVs are thought to play a prominent role in immune responses and are being championed as the long‐sought‐after mechanism for host‐induced gene silencing. However, parallel research on mammalian EVs is raising concerns about potential pitfalls faced by all EV researchers that will need to be addressed in order to convincingly establish that EVs are the primary mediators of small RNA transfer between organisms. Read the Tansley insight review: https://doi.org/10.1111/nph.16725 Rutter, B.D. and Innes, R.W. (2020) Growing pains: addressing the pitfalls of plant extracellular vesicle research. New Phytologist. doi: 10.1111/nph.16725 The New Phytologist Foundation is an independent, not-for-profit organisation dedicated to the promotion of plant science. It owns and produces the journals New Phytologist and Plants, People, Planet, and funds initiatives to support plant science, including symposia and workshops, awards for early career researchers, and ensuring free access to the Tansley reviews and insights series.