Diabetes, Insulin resistance in OA knee. PRS and metabolic correction is treatment скачать в хорошем качестве

Diabetes, Insulin resistance in OA knee. PRS and metabolic correction is treatment

It is not well known that Diabetes mellitus can contribute to OA knees. Insulin resistance (IR) has been linked to the development and progression of knee osteoarthritis (OA). Here are some key points about this relationship: Inflammation and Oxidative Stress: Insulin resistance can lead to chronic low-grade inflammation and oxidative stress, which are known to contribute to cartilage degradation and joint inflammation12. Metabolic Factors: Conditions like type 2 diabetes, which are characterized by insulin resistance, can exacerbate OA. High blood glucose levels and insulin resistance can promote the formation of advanced glycation end products (AGEs), which can damage cartilage3. Obesity and Joint Load: Insulin resistance is often associated with obesity, which increases the mechanical load on knee joints, further accelerating the wear and tear of cartilage2. Research Findings: Studies have shown that various indices of insulin resistance, such as the triglyceride glucose (TyG) index and its variants, are strongly associated with an increased risk of OA1. Managing insulin resistance through lifestyle changes, such as diet and exercise, and medical interventions can potentially help in reducing the risk and severity of knee osteoarthritis. Would you like more detailed information on managing insulin resistance or specific treatments for knee osteoarthritis? #diabetes #oaknee #prstreatmentchennai