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On September 24, 2020, Alex's Lemonade Stand Foundation (ALSF) presented a virtual childhood cancer lecture featuring Mariella G. Filbin, MD, PhD and Michelle Monje, MD, PhD. Dr. Filbin and Dr. Monje focused on how DIPG cells are regulated by intrinsic and extrinsic mechanisms and discuss how we may target these multiple mechanisms therapeutically. During this lecture, participants will: 1.) Understand how DIPG cells harbor aberrant chromatin/transcriptional states that can be shifted by epigenetic modulators. 2.) Understand how DIPG cells are activated by direct and indirect contacts with neurons and their electric activity. 3.) Learn about strategies for blocking both intrinsic and extrinsic pathways necessary for DIPG growth. To learn more about ALSF's Virtual Childhood Cancer Lecture Series and to register for upcoming presentations, visit https://www.alexslemonade.org/childho.... Other lectures of interest. Oncohistones: Prime Susceptibilities and Opportunities • Oncohistones: Prime Susceptibilities and O... Current & Future Direction of Clinical Trials for Pediatric CNS Tumors • Current Status and Future Direction of Cli... How Pediatric Brain Tumors Hide from the Immune System • Cloak & Dagger: How Pediatric Brain Tumors... Pediatric Brain Cancers as Epigenetic Diseases • Pediatric Brain Cancers as Epigenetic Dise... Precision Immunoncology for Childhood Cancers • Precision Immunoncology for Childhood Cancers Social Difficulties in Pediatric Brain Tumor Survivors • Social Difficulties in Pediatric Brain Tum... The Open Pediatric Brain Tumor Atlas Initiative • The Open Pediatric Brain Tumor Atlas Initi... Unleashing the Immune System Against Pediatric Cancers • Unleashing the Immune System Against Pedia... #DIPG #BrainTumor #ChildhoodCancer