Derm: Marjolin’s Ulcer: Free MSRA Podcast скачать в хорошем качестве

Derm: Marjolin’s Ulcer: Free MSRA Podcast

⚕️ FREE MSRA PODCAST – Marjolin’s Ulcer 🎧 A deep dive into this aggressive malignancy arising from chronic wounds – vital for exams and spotting danger in clinical practice. 🧠 Key Learning Points 📌 Definition Marjolin’s Ulcer is a rare but aggressive skin cancer, most often squamous cell carcinoma, arising from chronic non-healing wounds, burn scars, or longstanding ulcers. It has a long latency period (often decades) and carries a poor prognosis if missed. 📌 Causes & Risk Factors • Chronic non-healing wounds (especially burn scars) • Longstanding pressure ulcers • Chronic osteomyelitis sinuses • Repeated trauma or infection to scars • Immunosuppression (reduced immune surveillance) • Environmental carcinogen exposure 🧠 Memory Tip: "Burns and Beyond" – Think burns, bedsores, and chronic inflammation 📌 Pathophysiology • Chronic inflammation → ongoing repair → genetic mutations accumulate • Repeated cell turnover in damaged tissue triggers malignant transformation • Most commonly leads to SCC, but can also evolve into BCC or melanoma 📌 Symptoms • Non-healing ulcer at site of old scar or wound • New or worsening pain, bleeding, foul-smelling discharge • Induration (firmness), ulceration, or nodularity in scar • Irregular, raised, rolled borders • Changes after decades of stability 📌 Differential Diagnosis • Venous/arterial/diabetic ulcers • Pyoderma gangrenosum • Chronic traumatic ulcers • Primary cutaneous SCC • Infected scars 📌 Diagnosis • Biopsy is essential – confirms SCC or other malignancy • Examine regional lymph nodes • Ultrasound or CT imaging to check for local invasion or metastasis • Full staging needed for prognosis and management decisions 📌 Management • Multidisciplinary team (MDT) approach • Wide local excision with clear margins is first-line • Mohs surgery in sensitive locations • Reconstruction with skin grafts or flaps • Consider amputation if extensive local disease • Adjuvant radiotherapy or chemotherapy for incomplete resection or spread • Targeted therapy in select cases 📌 Complications • Local recurrence • Regional or distant metastases (e.g. lymph nodes, lungs, liver) • Functional loss from surgery/amputation • Poor wound healing • Psychological impact 📌 Prognosis • Depends on depth of invasion, tumour size, and presence of metastasis • Early diagnosis and full excision improve outcomes • Delay in recognition leads to high morbidity and mortality 🧠 Key Takeaway: Any sudden change in a longstanding wound or scar should raise alarm bells. Biopsy it. 📎 More MSRA Resources for Marjolin’s Ulcer 📝 Revision Notes: https://www.passthemsra.com/topic/mar... 🧠 Flashcards: https://www.passthemsra.com/topic/mar... 💬 Accordion Q&A Notes: https://www.passthemsra.com/topic/mar... 🚀 Rapid Quiz: https://www.passthemsra.com/topic/mar... 🧪 Topic Quiz: https://www.passthemsra.com/quizzes/m... 🎓 Full Dermatology Course: https://www.passthemsra.com/courses/d... 📣 All resources are part of the Dermatology for the MSRA course at: 👉 https://www.passthemsra.com Hashtags #MSRA #MSRARevision #MSRATextbook #MSRAQuiz #MSRAQuestionBank #MSRAFlashcards #MSRAQandANotes #MSRAAccordions #MultiSpecialtyRecruitmentAssessment #MarjolinsUlcer #Dermatology #ChronicWoundCancer #PassTheMSRA