Dr. Katie Schretter (HHMI Janelia) – Understanding Aggression: Neural Circuits in Drosophila скачать в хорошем качестве

Dr. Katie Schretter (HHMI Janelia) – Understanding Aggression: Neural Circuits in Drosophila

🌟 FlyComp2025 Guest Speaker Series: Episode 2 🌟 🧠 Understanding the Neural Circuits Underlying Aggression Using Drosophila 👩‍🎓 Have you ever wondered how, on a busy highway, our brain focuses precisely on the car in front of us while filtering out everything else happening around? More broadly, how do humans and animals adjust visual attention as their goals or environments change? We’re thrilled to host Dr. Katie Schretter for Episode 2 of the FlyComp2025 Guest Speaker Series! Dr. Schretter, Research Scientist in the Rubin Lab at HHMI Janelia (and incoming Assistant Professor at SMU), investigates these questions through the lens of female fruit flies during aggressive states. 💡 Howard Hughes Medical Institute (HHMI) is one of the world’s leading biomedical research organizations supporting curiosity-driven science. Since 1978, 35 HHMI-supported scientists have been awarded Nobel Prizes. At its Janelia Research Campus, HHMI has been at the forefront of synapse-level connectomics, mapping brain circuits to understand how neural networks give rise to behavior. 🗺️ Using connectomics, machine learning, behavioural experiments, and neural recordings, Dr. Schretter and her collaborators have: • Identified neuronal circuits involved in female aggression (Schretter et al., eLife, 2020) • Uncovered types of neurons regulating persistent female aggression (Chiu et al., eLife, 2023) • Revealed how social context, such as aggression, dynamically shapes a fly’s view of its world via three distinct mechanisms (Schretter et al., Nature, 2025) Dr. Schretter will take us inside the fascinating fly brain to show how environmental cues and internal states interact to shape social behaviour, leveraging cutting-edge tools in the fly world ranging from synapse-level connectomes, genetic tools, and neural activity insights! 🧬 Hosted by: Clematis Research Empowerment Hub, in partnership with the Gruntman and Anreiter Labs, University of Toronto. 📋 Read more about Dr. Schretter’s key works: • Schretter, C. E., ... & Rubin, G. M. (2020). Cell types and neuronal circuitry underlying female aggression in Drosophila. Elife, 9, e58942. https://elifesciences.org/articles/58942 • Chiu, H., ... & Schretter, C. E. (2025). Cell type-specific contributions to a persistent aggressive internal state in female Drosophila. Elife, 12, RP88598. https://elifesciences.org/articles/88598 • Schretter, C. E., ... & Rubin, G. M. (2025). Social state alters vision using three circuit mechanisms in Drosophila. Nature, 637(8046), 646-653. https://doi.org/10.1038/s41586-024-08... ➡️ Helpful Links • Website: https://flycomp2025.my.canva.site • Application Materials: https://tinyurl.com/flycomp2025 • Join Our Mailing List: https://tinyurl.com/flymail2025 • Submit Your Research Report: https://tinyurl.com/flyreport2025 • Neuroglancer: https://tinyurl.com/neuroglancerOptic... • neuPrint: https://neuprint.janelia.org/ · · ──────────────── · · 00:00 Pre-Session & Introduction 07:29 Neural Circuits Underlying Aggression 07:55 What Is a Social Behavior? 12:27 Phases of Aggression: Approach, Engage, Retreat 14:40 Outstanding Questions in Studying Aggression 15:30 Three Tools: Behavioral Analysis, Genetic Tools, and Connectomics 17:01 Visualizing and Manipulating Fly’s Behavior 18:01 aIPg Neurons Activation Promotes Continued Female Aggressive Behaviors 21:05 What Are Internal Aggressive States? 21:51 Do aIPg Neurons Promote Internal Aggressive States? 25:06 How Do Flies Know What to Attend to? 31:29 Using Synapse-Level Connectome To Study Vision-Mediated Aggression Circuits 33:48 Aggressive State Shapes Vision by Three Mechanisms 43:31 Aggressive Circuits in Male vs. Female 47:28 Circuit Mechanisms for Downregulating Aggression 51:28 General Framework for Social Decision-Making 53:36 Post-Session and Q&A