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The immune system works by recognising and attacking a particular substance that does not belong in the body (foreign cells). It does this by finding proteins on the surface of foreign cells, called antigens. T-cells (a type of immune cell) have receptors that attach to foreign antigens helping to trigger the immune system to destroy the foreign cells. CAR-T cell therapy is where the patient’s own T-cells are changed in the lab and given back to the patient boosting the patient’s immune system to identify the cancer cells and help destroy them. You can find out more about CAR-T cell therapy by watching the rest of the videos in the series, and on the CCLG website: https://www.cclg.org.uk/car-t-cell-th... These videos have been produced by Bath Spa University in conjunction with Great Ormond Street Hospital, Children’s Cancer and Leukaemia Group (CCLG) and Leukaemia Care. Our thanks to the families who have contributed and shared their experiences in the making of these videos. © 2022 CCLG