Cervical squamous intraepithelial neoplasia, CIN, conization, LEEP, LLETZ, endocervicoscopy скачать в хорошем качестве

Cervical squamous intraepithelial neoplasia, CIN, conization, LEEP, LLETZ, endocervicoscopy

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,[email protected], https://plus.google.com/communities/1... , ,https://plus.google.com/u/0/+Alexandr... ,    / @otolaryngologistorlent-med3259   ,    / @alexandrosg.sfakianakis4746   , https://twitter.com/g_orl?lang=el,   / alexandrossfakianakis  , Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study https://doi.org/10.1177/1533034617753811 Siavash Rahimi, MD, FRCPath1, 2, Carla Marani, MD3, Francis Gardner, MBBS, MD, FRCS, MRCOG4, Chit Cheng Yeoh, MBBS, BMedSc, MRCP, PhD5, Iolia Akaev, BSc5, Sergio Votano, MD6 1Pathology Centre-Histopathology, Queen Alexandra Hospital, Portsmouth, UK 2Department of Oncology, Queen Alexandra Hospital, Portsmouth, UK 3Division of Histopathology, San Carlo Hospital, Rome, Italy 4Department of Gynaecology, Queen Alexandra Hospital, Portsmouth, UK 5School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK 6Division of Gynaecology, San Carlo Hospital, Rome, Italy Corresponding Author: Siavash Rahimi, MD, FRCPath, Pathology Centre-Histopathology, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth PO6 3LY, UK. Emails: [email protected]; [email protected] The aim of this study was to investigate the practical utility of endocervicoscopy and targeted biopsy in high-risk human papilloma virus–positive women with abnormal squamous cells on cervical cytology and unsatisfactory colposcopy with nonvisible squamocolumnar junction. Seventy-seven high-risk human papilloma virus–positive patients with abnormal cervical cytology for squamous cells bearing type 3 transformation zone were enrolled. Endoscopic examination of the endocervical epithelium, with office-based continuous-flow hysteroscopy after application of acetic acid 5%, followed by targeted biopsies and consequent large loop excision of the transformation zone was carried out. Sensitivity, specificity, positive predictive value and negative predictive value of endocervicoscopy, and orientated biopsy were confronted with the results of large loop excision of the transformation zone (referral test). The sensitivity and specificity of endocervicoscopy and orientated biopsy for low-grade cervical intraepithelial neoplasia were 53% and 81%, respectively, while the sensitivity and specificity for high-grade cervical intraepithelial neoplasia were 64% and 47%, respectively. The positive predictive value for low-grade cervical intraepithelial neoplasia was 64% and for high-grade cervical intraepithelial neoplasia was 88%. The negative predictive value for low-grade cervical intraepithelial neoplasia was 87% and for high-grade cervical intraepithelial neoplasia was 41%. Endocervicoscopy is a safe, office-based technique. It is a reliable method to detect the transformation zone in patients with type 3 transformation zone and unsatisfactory colposcopy. It potentially allows target biopsy of the transformation zone but presents a relatively low specificity/negative predictive value to predict high-grade cervical intraepithelial neoplasia, thus negative biopsy results should be interpreted with caution. Keywords cervical squamous intraepithelial neoplasia, CIN, conization, LEEP, LLETZ, endocervicoscopy - video upload powered by https://www.TunesToTube.com