Toll-like receptor Signaling Pathway | MyD88 | TRIF Pathways | Basic Science Series скачать в хорошем качестве

Toll-like receptor Signaling Pathway | MyD88 | TRIF Pathways | Basic Science Series

My courses: https://www.researchgoal.com/goal/cou... Lokender Kumar Facebook:   / lokenderkumar.sharma   Facebook group for Biology Goal:   / 742235929758671   WhatsApp channel for Biology Goal: https://whatsapp.com/channel/0029Vas8... Facebook group for Microbe Goal:   / 409349399629712   Lokender Kumar LinkedIn Profile:   / dr-lokender-kumar-58525945   Research goal LinkedIn page:   / dashboard   WhatsApp channel for Research Goal: https://whatsapp.com/channel/0029Vb6M... 00:00 Introduction 02:07 RECAP 03:01 Structure of TLR 03:09 Activation of TLR 4 05:26 TIR Domain 07:04 Protein generated from Plasma Membrane 10:27 Protein generated from MYD 88 12:19 Some Important Proteins 15:17 Protein generated from Endosomal membrane 17:43 Summary 20:07 Conclusion Toll-like receptors, TLRs, PRRs, TLR4 = Toll like receptor 4, LPS = lipopolysaccharide (LPS), MD-2 = Myeloid Differentiation factor 2 (MD-2), CD14 = cluster of differentiation 14, IL-1R family members, TIR domain, MyD88: myeloid differentiation primary-response gene 88, universal adaptor TLRs (NOT -TLR3), TIRAP: Toll/interleukin-1 receptor domain-containing adapter protein, TRIF: TIR-domain-containing adaptor inducing IFNβ, TRAM: TRIF-related adaptor molecule (TRAM), TLR4 + LPS + MD-2 +CD14 complex, -TIR domain mediates downstream signaling, -MyD88-dependent or TRIF-dependent pathways, NF-kβ activation and MAPK activation, IFN Production, Pro-inflammatory cytokine production, Plasma membrane TLRs: TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10, Endosomal TLRs: TLR3, TLR7, TLR8, and TLR9 Pattern recognition receptors, innate immunity, C-type lectin receptors, NOD-like receptors, Pattern recognition receptors (PRRs), The function of the innate immune system, Detect molecules typical for the pathogens, Pathogen-associated molecular patterns (PAMPs), Membrane-bound PRRs include Toll-like receptors (TLRs) , C-type lectin receptors (CLRs), Cytoplasmic PRRs include NOD-like receptors, Toll-like Receptors (TRLs), Membrane receptors, Macrophages and dendritic cells Recognition and response to foreign pathogens Pro-inflammatory and effector cytokines Common structural framework Horseshoe-shaped structures (leucine-rich repeat motifs), 22–29 residues in length. ‘‘m’’-shaped dimer sandwiching the ligand molecule bringing the transmembrane and cytoplasmic domains in close proximity TLR extracellular domains with their ligands vary markedly between TLR paralogs. TIR domains on the adaptor proteins MyD88, TRIF, and TRAM, TLRs and their ligands Unmethylated CpG Oligodeoxynucleotide DNA Support my work at https://www.patreon.com/user?u=37177596 Twitter:   / drkumarlokender   Facebook:   / lokenderkumar.sharma   Linkedin:   / dr-lokender-kumar-58525945   Disclaimer: The information provided is for educational purposes only. The content of this channel should not be considered as medical advice of any kind. Please consult your doctor for medical help. Use this information at your own risk. We hold no responsibility for any issue, concerns, or damage arising from the content of the video. Under no circumstances Basic Science Series English be responsible or liable in any way for any content, including but not limited to, any errors or omissions in the content, any loss, any damage of any kind incurred as a result of any content communicated in this video, whether by Basic Science Series English or a third party. In no event shall Basic Science Series English be liable for any special indirect or consequential damages of any damages whatsoever resulting from the content of our channel.