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The Spring 2025 WiCOR Lecture was presented by Nobel Laureate Jack Szostak (Univ. of Chicago) on May 1 at the University of Wisconsin-Madison. Title: The Origin of Life: Easy or Hard? Abstract: The combined efforts of laboratories around the world have begun to converge on a reasonable pathway going all the way from planet formation to the beginnings of life itself. Many deeply embedded preconceptions have had to be overcome and discarded in order to enable progress. I will explain how overcoming these conceptual barriers has enabled fresh thinking into how the molecules of life were synthesized on the early Earth and then assembled into the first living cells. Once the ability of life to evolve in a Darwinian sense had become firmly established, life was free to adapt, diversify, and flourish, eventually giving rise to all the varieties of life we see around us today.