Discovery, regulation and function of the PI 3-Kinase and AKT pathway in cancer скачать в хорошем качестве

Discovery, regulation and function of the PI 3-Kinase and AKT pathway in cancer

Alex Toker Professor of pathology, Harvard Medical School Associate director of the Cancer Research Institute, Beth Israel Deaconess Medical Center Toker’s research focuses on signal transduction mechanisms in normal and malignant cells. His lab discovered mechanisms by which PI3K signals to the protein kinase effector AKT, and has since maintained an active interest in AKT regulation and function. His group discovered specific functions of AKT in breast cancer and more recently has been investigating the reprogramming of metabolic pathways by aberrant PI3K and AKT signaling. The current goal of his laboratory is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs to interfere with malignancy. The ASBMB Breakthroughs webinar series offers a window into the cutting-edge biochemistry and molecular biology research driving discovery.