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In Day 7 – Lecture 8 (dated 23 December 2025), this session focuses on domain and motif identification using the NCBI Conserved Domain Database (CDD) and their integration with phylogenetic analysis as part of genome-wide and gene family studies. The lecture component explains the theoretical background of protein domains, conserved motifs, and their evolutionary significance, while the practical segment demonstrates how to identify domains and motifs using NCBI CDD, interpret CDD outputs, and correlate motif/domain architecture with phylogenetic tree topology. This session is especially useful for students and researchers working on gene family characterization, functional annotation, comparative genomics, and evolutionary biology. The workflow discussed in this lecture is applicable to plant, animal, and microbial genomes, and is commonly used in genome-wide analysis pipelines. Hashtags #NCBICDD #ConservedDomains #MotifAnalysis #PhylogeneticAnalysis #GenomeWideAnalysis #GeneFamilyAnalysis #BioinformaticsLecture #ComputationalBiology #ProteinDomains #EvolutionaryBiology #LectureAndPractical Keywords (Tags) NCBI CDD, conserved domain database, protein domain analysis, motif analysis, domain and motif identification, phylogenetic tree analysis, gene family analysis, genome wide analysis, functional annotation, bioinformatics practical, bioinformatics lecture, comparative genomics, evolutionary analysis, protein sequence analysis, molecular evolution, plant genomics, bioinformatics workflow