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Understanding microbial interactions is a fundamental objective in microbiology and ecology. The synthetic community system described here can set into motion a range of research to investigate how the diversity of a microbiome and interactions among its members impact its function, where function can be measured as exometabolites. The system allows for community exometabolite profiling to be coupled with genome mining, transcript analysis, and measurements of member productivity and population size. It can also facilitate discovery of natural products that are only produced within microbial consortia. Thus, this synthetic community system has utility to address fundamental questions about a diversity of possible microbial interactions that occur in both natural and engineered ecosystems. DOI: https://doi.org/10.1128/mSystems.0012... Title: A Synthetic Community System for Probing Microbial Interactions Driven by Exometabolites Authors: John L. Chodkowski, Ashley Shade (http://orcid.org/0000-0002-7189-3067) Editor: Pieter C. Dorrestein Published in mSystems® on 14 November 2017 👍 Subscribe to ASM's YouTube channel at https://goo.gl/mOVHlK 🔬 Learn more about the American Society for Microbiology at http://www.asm.org ✅ Become a member today at http://www.asmscience.org/join 📱 Interact with us on social at: Facebook Show your support and get updates on the latest microbial offerings and news from the ASM. / asmfan ASM International Facebook Groups Join an ASM International Facebook Group and connect with microbiologists in your region. http://www.asm.org/index.php/programs... Twitter Follow all the latest news from the Society. / asmicrobiology Instagram Outstanding images of your favorite viruses, fungi, bacteria and parasites / asmicrobiology