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Animal research plays an essential role in our understanding of health and disease and in the development of modern medicine and surgical techniques. As part of our commitment to openness, this film examines how mice are helping the fight against cancer. It takes a in-depth look at the facilities in which they are housed, exploring issues of animal welfare and the search for replacements. We welcome comments about this article. However, as with discussions on all of our news and feature pages, comments will be moderated so please do not post contributions that are offensive or contain profanities and do stay on topic. We do not moderate comments in real-time so do bear with us if there is a delay before they appear. Since this film was published, there has been considerable evidence-based research for improved welfare and scientific outcomes to non-tail handling mice.