Cannabinoids & Endocannabinoid System in ASD - A. Aran MD, Shaare Zedek Medical Center @Sychrony2020 скачать в хорошем качестве

Cannabinoids & Endocannabinoid System in ASD - A. Aran MD, Shaare Zedek Medical Center @Sychrony2020

In this talk Dr. Aran describes possible roles of the endocannabinoid system in the pathogenesis of Autism, and discusses the current evidence for cannabinoid treatment in ASD including a still unpublished randomized study. After the talk, there is a 5 minutes for questions and comments. Dr. Aran's research projects over the past years combine basic science with bedside clinical observations. Examples include: researching the genetic basis of familial microcephaly in a local cohort and uncovering the affected protein and its function (Aran et al, Neurology 2016) and similar projects on congenital pre-synaptic myasthenia gravis (Aran et al, Neurology 2017), progressive cerebellar atrophy (Langer & Aran et al, J Med Genet 2018) and intellectual disability with refractory seizures (Segel & Aran et al, Neurogenetics 2020). In recent years, Dr. Aran has focused his efforts on understanding the role of the endocannabinoid system in ASD and assessing the therapeutic effects of cannabidiol-based medical cannabis. Dr. Aran and his team have initiated the first studies exploring the effects of cannabidiol-rich cannabis in children with ASD, a subject that is getting now a lot of public attention worldwide. In the first study (Aran et al, JADD 2019) they demonstrated the feasibility of whole plant extracts of cannabidiol-rich strains, in 60 children with ASD and severe resistant behavioral problems. Following this study, they have conducted a double-blind, placebo-controlled trial in 150 children with ASD, to compare the efficacy of pure cannabinoids and a whole plant extract that preserve a possible entourage effect. As part of this study they have measured baseline circulating endocannabinoids and found substantially lower levels in children with ASD compared with a matched control group. These findings corroborate in humans, previous studies in animal models that demonstrated dysregulation of the endocannabinoid system in ASD and suggest a therapeutic role for cannabidiol. (Aran et al, Mol. Autism 2019). Arthur Krigsman, MD is a pediatrician and pediatric gastroenterologist with expertise in the evaluation and treatment of autism associated gastrointestinal problems. His interest in this unique patient population began in 2001 and during the ensuing 17 years he has treated over 1900 children from across the globe suffering from autism and a variety of gastrointestinal problems. His research interest lies in the characterization of the unique cellular, molecular, and clinical features of ASD-associated inflammatory bowel disease and his original findings appear in numerous peer-reviewed journals. In addition to serving as an invited reviewer for peer-reviewed medical journal author submissions in his area of expertise, Dr. Krigsman has served as a guest lecturer on the topic of gastrointestinal disease and autism at national and international scientific meetings, hospital Grand Rounds both here and abroad, Nurse Association meetings, philanthropic organizations, and at numerous lay medical conferences. He has also presented his findings before the U.S. Congress. His greatest satisfaction though derives from the clinical care he provides his patients and in the improved quality of life that results from diagnosing and treating gastrointestinal disease in this vulnerable population. #Cannabinoid #medicalcannabis #cbd #thc This talk was part of Synchrony 2020 Online Symposium - 'From Bench to Biopharma', organised by the The BRAIN Foundation in partnership with UC Davis MIND Institute and CalTech. For more Synchrony 2020 talks and highlights:    • Synchrony Symposium 2020 - From Bench To B...   🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 Synchrony https://synchronysymposium.com/ is the first and only international symposium on translational research in #autism, that brings together academia, #biotech, pharmaceutical companies and #venture partners from around the world with the mission to improve health and quality of life of people with #autismspectrumdisorder. 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 The BRAIN Foundation https://brainfoundation.org/ is a 501c(3) non-profit. The founders of BRAIN envision a world where every child and adult on the autism spectrum is healthy, participates fully in education and employment, and has a better quality of life. It aims to catalyze research that results in evidence-based interventions for the disabilities associated with autism, and also results in better medical standard of care. To accomplish this, it funds impactful research through #philanthropy and our network of partners in the venture, corporate, and grassroots community.