FAAH: a promising cannabis alternative for enhancing brain endocannabinoid tone скачать в хорошем качестве

FAAH: a promising cannabis alternative for enhancing brain endocannabinoid tone

Today we discuss the endocannabinoid system (ECS), focusing on the enzyme fatty acid amide hydrolase (FAAH) and its role in degrading the endocannabinoids anandamide and oleamide. We'll explore the influence of diet on the ECS, particularly highlighting superfoods that contain anandamide or inhibit FAAH activity. We'll talk about the potential therapeutic benefits of FAAH inhibitors in treating conditions like depression, pain, and neurological diseases. We'll delve into the research on biochanin A, a naturally occurring isoflavone found in red clover, and its potent inhibitory effects on FAAH both in vitro and in vivo. Finally, the third text compares different routes of administration for FAAH inhibitors, focusing on the efficacy of intranasal delivery of URB597 and PF-04457845 compared to oral or intraperitoneal routes.