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Orthotopic Mouse Model of Colorectal Cancer

Reference: https://app.jove.com/v/484/orthotopic... The Colorectal Cancer Orthotopic Mouse Model is a widely utilized research model that involves the implantation of colorectal cancer cells into the colon or rectum of mice. This model closely mimics the development and progression of colorectal cancer in humans, making it an invaluable tool for studying the disease and testing potential therapeutic interventions. To establish the orthotopic mouse model, colorectal cancer cells are typically injected directly into the colon or rectal wall of immunocompromised mice. This method ensures that the tumor grows in its natural anatomical location, allowing researchers to investigate the tumor microenvironment, tumor-host interactions, and the metastatic potential of the cancer cells. Once the tumor is established, researchers can monitor its growth and progression using various imaging techniques, such as ultrasound, magnetic resonance imaging (MRI), or bioluminescence imaging. These non-invasive imaging methods enable longitudinal studies, providing valuable insights into tumor growth kinetics, response to treatment, and metastasis. The Colorectal Cancer Orthotopic Mouse Model offers several advantages over other preclinical models. Firstly, it allows researchers to study the complex interactions between the tumor and its microenvironment, including the immune system, stromal cells, and blood vessels. This is crucial for understanding the mechanisms underlying tumor growth, invasion, and metastasis.