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Over the past two decades since the human genome was first sequenced, high-throughput sequencing technologies have transformed biomedical research. Robert (Bob) Waterston was instrumental in pushing for an open science approach to the Human Genome Project, drawing on the success of mapping and sequencing the genome of the nematode worm. To commemorate the 20th anniversary of the publication of the first draft human genome sequence, the Nature Milestones in Genomic Sequencing project caught up with Bob to hear about his personal experience of this landmark international effort. Read more in https://www.nature.com/immersive/d428... Watch the other film in this series • How ancient DNA sequencing changed the game This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here: https://partnerships.nature.com/comme... Sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday: https://go.nature.com/371OcVF