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Managing Gilbert's Syndrome

Around 10% of the UK population has Gilbert’s syndrome, yet only 3% percent are ever diagnosed. Gilbert’s is caused by a defect in the UGT1A1 gene, which reduces the body’s ability to break down fats and impairs phase two detoxification. This often appears on blood work as elevated bilirubin, sometimes approaching levels associated with jaundice. For those with Gilbert’s, supporting bile flow and enhancing glucuronidation with interventions such as TUDCA, ox bile, bitter vegetables, or calcium D-glucarate can play an important role in maintaining health.