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NCLEX Bootcamp Free Resources: Free NCLEX Cheat Sheets - https://bootcamp.com/nclex/free-resou... Free NCLEX Practice Cases and Video Explanations - https://bootcamp.com/nclex Antidepressants are always tested on the NCLEX® and this video breaks down everything you need to know to stay safe on exam day and in clinical practice. ✅ What You’ll Learn: 1. Core antidepressant safety rules (slow onset, suicide risk, serotonin syndrome) 2. SSRIs: sertraline, fluoxetine, paroxetine — sexual dysfunction, bleeding risk, withdrawal 3. SNRIs: duloxetine, venlafaxine — dual action, hypertension precautions 4. TCAs: amitriptyline, imipramine — cardiac toxicity, sedation, anticholinergic effects 5. MAOIs: phenelzine, selegiline — tyramine foods → hypertensive crisis 6. Others: bupropion (↓ seizure threshold), mirtazapine (sedation, weight gain) 7.Serotonin Syndrome: “Sweating, Shaking, Strange behavior” — emergency care ⏱️ Timestamps 0:00 – Intro: Antidepressants overview & NCLEX expectations 0:13 – What all antidepressants have in common 0:20 – Onset of action: takes several weeks to work 0:28 – Key teaching: consistency & patience 0:36 – NCLEX safety: suicide risk (especially in youth) 0:51 – Serotonin syndrome overview (life-threatening complication) Serotonin Syndrome 1:15 – Causes: multiple serotonergic meds (SSRIs, SNRIs, MAOIs, St. John’s wort, triptans) 1:19 – The “3 S’s” of serotonin syndrome: • Sweating (fever, ↑HR, ↑BP) • Shaking (tremor, hyperreflexia, rigidity) • Strange behavior (agitation, confusion, hallucinations) 1:45 – NCLEX emergency: hold meds & notify provider 2:03 – Avoid St. John’s wort with antidepressants SSRIs – Selective Serotonin Reuptake Inhibitors 2:22 – SSRIs explained: citalopram, fluoxetine, paroxetine, sertraline 2:41 – Why they’re first-line: depression & anxiety 2:48 – Common side effects: GI upset, sexual dysfunction, sleep disturbance 3:10 – Rare risk: ↑ bleeding (esp. with NSAIDs or anticoagulants) 3:28 – Teaching: do not stop abruptly → withdrawal symptoms 3:50 – Reminder: takes weeks to work, stay consistent SNRIs – Serotonin Norepinephrine Reuptake Inhibitors 4:00 – Examples: duloxetine, venlafaxine 4:12 – Dual action: serotonin + norepinephrine 4:18 – Used for depression & neuropathic pain (fibromyalgia, diabetic neuropathy) 4:22 – Side effects: GI upset, insomnia, ↑ blood pressure 4:35 – Nursing priority: check baseline BP & avoid if hypertensive NCLEX Quick Check #1 4:54 – How long for antidepressants to work? (weeks) 5:09 – Main safety risk? (suicidal ideation early in therapy) 5:26 – Serotonin syndrome 3 S’s 5:42 – Avoid St. John’s wort TCAs – Tricyclic Antidepressants 5:52 – Examples: amitriptyline, imipramine, nortriptyline 6:04 – Major risk: cardiac toxicity & fatal overdose 6:16 – ECG before starting; never double doses 6:26 – Common side effect: orthostatic hypotension 6:39 – Anticholinergic side effects: dry mouth, constipation, urinary retention 6:50 – Nursing care: fluids, fiber, sugar-free candy, slow position changes 6:54 – Sedation → best taken at bedtime MAOIs – Monoamine Oxidase Inhibitors 7:03 – Examples: isocarboxazid, phenelzine, selegiline 7:14 – Rarely used but high-yield on NCLEX 7:24 – Major danger: hypertensive crisis (pounding headache) 7:27 – Avoid tyramine foods: aged cheese, salami, beer, wine 8:03 – Serotonin syndrome risk: do not mix with SSRIs, TCAs, St. John’s wort, triptans 8:28 – 2-week washout period before starting new antidepressant Other Antidepressants 8:43 – Bupropion (Wellbutrin): ↑ dopamine & norepinephrine 8:57 – Lowers seizure threshold → avoid in seizure disorders, eating disorders, alcohol withdrawal 9:10 – Mirtazapine: promotes sleep & appetite → sedation & weight gain 9:17 – Avoid mixing with alcohol or CNS depressants NCLEX Quick Check #2 9:39 – Foods to avoid with MAOIs → tyramine (aged cheese, salami, wine) 9:54 – Who should not take bupropion? → clients with seizures or eating disorders 10:01 – Wrap-up: antidepressants NCLEX review summary NGN Strategy Course Playlist - https://app.bootcamp.com/nclex/next-g... Follow us on Social: Study Group - / nclexbootcampstudentgroup Facebook - / nclexbootcampoffical Instagram - / nclexbootcamp TikTok - / nclex_bootcamp _______________________________________________________________ antidepressants NCLEX, antidepressants nursing, SSRI NCLEX, SNRI NCLEX, MAOI NCLEX, tricyclic antidepressants NCLEX, bupropion NCLEX, serotonin syndrome NCLEX, antidepressant teaching NCLEX, antidepressant side effects NCLEX, St John’s wort NCLEX, serotonin syndrome nursing, hypertensive crisis MAOI NCLEX, antidepressant medications nursing school, NCLEX pharmacology antidepressants, nursing pharmacology mental health, antidepressant safety NCLEX, NCLEX mental health review