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Why does precision matter in intraosseous injections for knee arthritis? In this video, Dr. Chris Centeno explains why fluoroscopy with contrast is essential for targeting bone marrow lesions during orthobiologic procedures like bone marrow concentrate or PRP injections. Dr. Centeno shares key research showing that bone marrow lesions—not cartilage damage or meniscus tears—correlate most with knee pain. You’ll learn the origin of intraosseous treatments, the limitations of “blind” injections without imaging, and real contrast injection visuals that prove just how easy it is to miss the mark without fluoroscopic guidance. Dr. Centeno is a founding physician in the field of interventional orthobiologics and leads the team at the Centeno-Schultz Clinic—where advanced imaging is standard in every procedure. 🔔 If you find this content helpful, please like, comment, and subscribe to stay informed. / @centenohome To schedule a telemedicine or in-person visit, call +1-303-429-6448 or email us at [email protected]. Dr. Centeno also answers questions on his Reddit thread at / picl Join him for weekly Facebook Lives at / centenoschultzclinic to learn more. Download Dr Centeno's book on craniocervical instability at https://centenoschultz.com/craniocerv... Join CCI Communities: PICL SubReddit: https://www.reddit.com/r/PICL/?rdt=58942 PICL Facebook Group: / ccjpicl Follow us for updates and news: Website: https://centenoschultz.com/ https://regenexx.com/ Facebook: / centenoschultzclinic Instagram: / centenoschultzclinic LinkedIn: / chris-centeno-m-d-b6838024 Centeno-Schultz Clinic 403 Summit Blvd Suite 201 Broomfield, CO 80021 303-429-6448 Key Timestamps: 00:00 Why fluoroscopy is critical for intraosseous injections 00:15 Bone marrow lesions as the key source of knee pain 00:59 History of intraosseous orthobiologics and Regenexx trial 02:05 Risks of blind or inaccurate injection techniques 02:28 Real case example: difficulty targeting lesions despite high volume 04:33 Conclusion: precision matters for optimal results