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Intra-arterial chemotherapy methods for CNS tumours

Dr Pearl talks to ecancertv at Children with Cancer UK’s workshop on Drug Delivery in Paediatric Brain Tumours in London, UK. In the interview she discusses her work on intra-arterial chemotherapy for central nervous system tumours. Dr Pearl explains that her research largely focuses on diffuse intrinsic pontine gliomas (DIPG), which is not amenable to surgical resection. Getting drugs across the blood-brain barrier to treat this paediatric brain tumour remains a challenge and one approach Dr Pearl and colleagues are investigating is intra-arterial administration. They have started a pilot study in children with recurrent DIPG and so far two of a planned five children have been recruited. So far they have seen that intra-arterial administration is technically feasible and appears well tolerated.