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This presentation, delivered by Dr. Jerome Razanamahery from Dijon University Hospital, France, was part of the Medical Symposium on Day Two of the ECDGA event in Barcelona, Spain (May 27, 2025). The seminar focuses on the role of MAPK-kinase mutations and aortic lesions in shaping the distribution of circulating monocytes in histiocytosis. Dr. Razanamahery explores how these molecular and vascular factors are linked to disease progression, patient outcomes, and future directions for targeted therapies. This video is one of the recorded sessions from the symposium, where leading experts in histiocytosis shared the latest clinical and research updates. Viewers will gain insights into: The molecular pathways involving MAPK-kinase in histiocytosis Associations between vascular lesions and immune cell distribution Implications for diagnosis, monitoring, and therapy in patients with histiocytic disorders For more sessions from this program, see the full ECDGA Medical Symposium agenda from Day Two.