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Mushroom Health Spectrum Research findings on the multifaceted health benefits of edible mushrooms, focusing on their role in mitigating subclinical thyroid dysfunction, combating obesity, and offering broad therapeutic potential. A large-scale prospective cohort study has demonstrated for the first time that higher consumption of edible mushrooms is significantly associated with a lower incidence of subclinical hypothyroidism, with a particularly pronounced effect observed in obese individuals. Beyond thyroid health, mushrooms are identified as nutritional powerhouses rich in bioactive compounds such as polysaccharides (β-glucans), flavonoids, terpenes, and ergothioneine. These compounds contribute to potent anti-obesity, anti-inflammatory, antioxidant, and hypolipidemic effects. The mechanisms of action are diverse, including the modulation of gut microbiota, inhibition of cholesterol synthesis, reduction of hypertension via ACE inhibition, and enhancement of the body's immune and antioxidant defense systems. Research underscores mushrooms' potential as functional foods and sources of nutraceuticals for the prevention and management of chronic metabolic diseases. References A review of the effects of mushrooms on mood and neurocognitive health across the lifespan https://www.sciencedirect.com/science... Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study https://library.kab.ac.ug/Record/doaj... Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products https://www.mdpi.com/2304-8158/14/5/741 Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms https://onlinelibrary.wiley.com/doi/1... Anti-Obesity Effects of Medicinal and Edible Mushrooms https://pmc.ncbi.nlm.nih.gov/articles... Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort studyhttps://www.researchgate.net/figure/A... Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study https://www.researchgate.net/publicat... Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study https://www.sciopen.com/article/10.10... Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study https://www.sciencedirect.com/science... A critical review on the health promoting effects of mushrooms nutraceuticals https://www.sciopen.com/article_pdf/1... Edible Mushrooms as Novel Myco-Therapeutics: Effects on Lipid Level, Obesity, and BMI https://pmc.ncbi.nlm.nih.gov/articles... Mushrooms https://nutritionsource.hsph.harvard.... Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey https://www.frontiersin.org/journals/... Edible Mushrooms, a Sustainable Source of Nutrition, Biochemically Active Compounds and Its Effect on Human Health https://www.intechopen.com/chapters/8... Mushrooms and Human Health: Recent Research and Future Opportunities—Insights From a Recent Mini-summit on Mushrooms https://www.researchgate.net/publicat... Psilocybin desynchronizes the human brain https://www.nature.com/articles/s4158... Effects of Consuming Ultraviolet Light-Exposed Mushrooms on Self-Reported Indices of Brain Health and Performance-Based Cognition in Middle-Aged and Older Adults https://www.mdpi.com/2304-8158/14/18/... Edible Mushrooms: Improving Human Health and Promoting Quality Life https://pmc.ncbi.nlm.nih.gov/articles...