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cholestatic pruritus

Itchiness (pruritus) caused by cholestasis. It is a very common clinical consequence of cholestasis. Cholestasis is a liver disease, which occurs when the flow of bile from the liver is reduced or blocked, leading to a buildup of bilirubin. Nearly any liver disease can cause it. (Liver diseases that may cause itch) • primary biliary cirrhosis • primary sclerosing cholangitis • obstructive choledocholithiasis • carcinoma of the bile duct • viral hepatitis (e.g. chronic hepatitis C viral infection) (Causes) Although, liver disease with significant elevations of serum bile salts causes itchiness, unconjugated hyperbilirubinemia does not typically cause it. Substances excreted in the bile accumulate in the body tissues and seem to stimulate peripheral pruriceptive neurons, that cause itch. (Substances that may cause itch) • bile acids • endogenous opioid • serotonins • lysophosphatidic acid