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Aslam o alikum I am Hassam ur Rahman and I am teaching Fsc biology since 2014 .I am always trying to improve myself and provide best lecture to students.i am taking content for the lecture from authentic and relevant sources but human errors are possible . you are requested to please highlight the mistakes.My lectures are equally reliable for Fsc and mdcat students #visiblescience #mdcatbiology #alevelbiology #neetbiology #fscbiology #transgenicanimals #cloning This lecture is about Transgenic Animals Techniques have been developed to insert genes into the eggs of animals. It is possible to micro eggs by hand, but another method uses vortex mixing. The eggs and silicon - carbide needles, and the needles make DNA can enter. When these eggs are fertilized, the resulting offspring are transgenic animals. Using this technique many types of animal eggs have taken up the gene for bovine growth hormone. The procedure has been used to produce larger fishes’, cows, pigs, rabbits and sheep. Genetically engineered fishes are now being kept in ponds that offer no escape to the wild because there is much concern that they will upset or destroy natural ecosystems.Gene pharming, the’ use of transgenic farm animals to produce pharmaceuticals is being pursued by a number of firms. Genes that code for therapeutic, and diagnostic proteins are incorporated into the animal’s DNA, and the proteins appear in the animal’s milk. There are plans to produce drugs for the treatment of cystic fibrosis, cancer, blood diseases and other disorders. Antithrombin III, for preventing blood clot during surgery, is currently being produced by a herd of goats, and clinical trials have begun. Figure 23.10 out lines the procedure of producing transgenic mammals. DNA containing the gene of interest is injected into donor eggs. Following in vitro fertilization, the zygotes are placed in host females where they develop. After female offspring mature, the product is secreted in the milk. The scientists of United States Departmentof Agriculture have been able to genetically engineer mice to produce human growth hormone in their urine instead of in milk. They expect to be able to use the same technique on larger animals. Urine is a preferable vehicle for a biotechnology product than milk because all animals in a herd urinate - only females produce milk; animals start to urinate at birth - females don’t produce milk until maturity; and its easier to extract proteins from urine than from milk.