Sarcoidosis, pathophysiology clinical aspects and management скачать в хорошем качестве

Sarcoidosis, pathophysiology clinical aspects and management

Please read and agree to the disclaimer before watching this video. . Subscribe to the drbeen Channel HERE: http://bit.ly/2GBhiS0 For more content from drbeen, click HERE: http://bit.ly/2GB41bU Watch drbeen videos HERE: http://bit.ly/2GB41bU Like drbeen on Facebook HERE: http://bit.ly/2GSSTGS Follow drbeen on Twitter HERE: http://bit.ly/2XeSVhV Follow drbeen on Instagram HERE: http://bit.ly/2ST2Zih Get new medical lectures across your devices. Stream anywhere, anytime. Try it for free! http://bit.ly/2QsIwQ5 Sarcoidosis is discussed as part of restrictive lung diseases. We will discuss: The connection of Sarcoidosis with the respiratory system. Definition: A non-caseating granulomatous disease of unknown etiology involving multiple systems. Guidelines for the diagnosis: TB, Fungi, Viruses, and other agents (Borrelia) can cause non-caseating granulomas. Demography: Genetics, immune disorders (CD4 cell dysregulation), HLA-B1, HLA-B8, African Americans, women more than men, young patients, non-smokers. Pathogenesis: Mechanism of production of non-caseating granuloma. Antigen's arrival. Antigen presenting cells' (APCs) response. CD4 cells in the lymph nodes (hilar and paratracheal) get involved. IL2 release. The monoclonal proliferation of the CD4 cells. IL4-IL5 release leading to polyclonal B cell proliferation in the lymph nodes. IFN-gamma release. Activation of macrophages. The release of IL8, TNF, MIP-1alpha. Epithelioid cell formation. Multinucleated giant cell formation. Granuloma formation. A ring of CD4 cells around the granuloma. Concentric deposition of Ca++ and proteins inside the cells. Schaumann bodies. Asteroid body formation. Organs involved. Skin lesions on the scalp, nose, cheeks, and the lips. Even on the back and neck. Lupus Pernio. Painful lesions (erythema nodosum) on the front of the legs. Pituitary gland involvement. Resulting in diabetes inspidus. Meningitis. Parotid gland involvement leading to xerostomia. Eye involvement Lacrimal gland inflammation - sicca syndrome. Pericarditis of the heart. Hilar lymphadenopathy. Paratracheal lymphadenopathy. Liver and spleen enlargement due to granulomas in the liver. Clinical aspects: In some patients, ACE enzyme increases. Alpha-1 hydroxylase is increased which in turn causes hypercalcemia. Hypercalcemia occurs. 10-15% of patients will develop progressive interstitial fibrosis with poor prognosis. Usually resolves automatically. Steroid can be given. TNF blockers can also slow down this disease. ... Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ... Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.