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The Dark Side of Finasteride Although it is widely used to treat hair loss and prostate enlargement, finasteride has a “dark side” related to the inhibition of the 5α-reductase enzyme, which blocks the synthesis of hormones and neurosteroids essential for brain function. This biochemical disruption can trigger serious adverse effects, such as erectile dysfunction, loss of libido, and deep depression, which in a subset of patients become persistent or even irreversible, drastically impacting quality of life and mental health. Imagine finasteride acting like a switch that turns off not only prostate growth or unwanted hair loss, but also the “electricity” required for sexual and emotional well-being; in some individuals, the system has difficulty turning that switch back on even after the medication is discontinued. Traish AM, Mulgaonkar A, Giordano N. The dark side of 5α-reductase inhibitors’ therapy: sexual dysfunction, high Gleason grade prostate cancer and depression. Korean J Urol. 2014;55(6):367–379. Share this content so more people can access this important information. This video is for informational purposes only and does not replace a medical consultation. If you use this medication or experience symptoms, it is essential to talk to your physician to assess the risks and the best options for your case. #finasteride #pfs #menshealth #sideeffects #mentalhealth #erectiledysfunction #libido #depression