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HOW LONG Does It Takes To Activate AUTOPHAGY? | Dr Ana Maria Cuervo Interview Clips

Dr Ana Maria Cuervo talks about time needed to activate autophagy are different depends on which type of autophagy. In mammalian cells, there are three primary types of autophagy: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). While each is morphologically distinct, all three culminate in the delivery of cargo to the lysosome for degradation and recycling Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly translocated across the lysosome membrane for degradation. Two types of autophagy are conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy, autophagosomes deliver cytoplasmic constituents to endosomes or lysosomes, whereas during microautophagy lytic organelles take up cytoplasm directly. Dr Ana Maria Cuervo is co-director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. In 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders. Dr Cuervo’s group is interested in understanding how altered proteins can be eliminated from the cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy) with different neurodegenerative diseases including Parkinson’s, Alzheimer’s and Huntington’s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pionered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #autophagy #CMA #macroautophagy #spermidine #metformin #rapamycin #DrCuervo #DavidSinclair #Sirtuins #Epigenetic #Mitochondria #ALA #Metformin #PQQ #CoQ10 #Carnitine #Antioxidant #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #Resveratrol #aging #Lifespan #NMN #NR #berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome #davidsinclair