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#DiabeticFootUlcers #AdvancedWoundCare #LimbSalvage #WoundHealing #Neuropathy #Offloading #CollagenTherapy #BioengineeredSkin #HBOT #NPWT #StemCells #Podiatry #VascularSurgery #WoundCareSpecialist #DiabetesComplications Globally, over 400 million people live with diabetes, and a quarter will develop a diabetic foot ulcer (DFU). Neuropathy increases amputation risk by 15 times, leading to significant limb loss annually. Diabetic wounds often get stuck in the inflammatory phase due to underlying issues like nerve damage, poor blood flow, infection, and high blood sugar. This necessitates advanced techniques beyond standard care. The video explores various advanced modalities drawing from "Limb Salvage of the Diabetic Foot". Collagen-based therapies provide scaffolding, boost cell proliferation, and manage destructive enzymes (MMPs). Examples include bioengineered skin substitutes like Apograft (living cells, dermoo inductive), Dermograft (cryopreserved dermal substitute, stimulates epithelialization), and TheraSkin (living allograft, rich in growth factors/collagen, avoids donor site). Structural scaffolds like Integra/Omnigraft and Graph Jacket guide tissue growth, while dressings like Promagran/Prisma bind MMPs and Fibricol Plus manage exudate. Other techniques discussed include Hyperbaric Oxygen Therapy (HBOT) which floods tissues with oxygen to overcome hypoxia and fuel healing, Low-Level Laser Therapy (LLLT) stimulating cellular activity, Ultrasonic Debridement using ultrasound and saline to clean wounds and disrupt biofilm, Electrical Stimulation mimicking natural currents to accelerate healing and fight bacteria, and Negative Pressure Wound Therapy (NPWT/VAC) using suction to promote blood flow, granulation, and remove fluid/bacteria. Emerging Stem Cell Therapy shows promise for stubborn ulcers by boosting revascularization and repair. These advanced treatments, used as part of a multidisciplinary, patient-specific approach, aim not just to heal the wound but to prevent recurrence, reduce amputations, and preserve mobility and quality of life.