EP 189: From genetic heritability in twins to gut health with Tim Spector of King’s College and Zoe скачать в хорошем качестве

EP 189: From genetic heritability in twins to gut health with Tim Spector of King’s College and Zoe

Summary: This week on The Genetics Podcast, Patrick is joined by Tim Spector, Professor of Genetic Epidemiology at King’s College London and co-founder of Zoe. They discuss surprising insights on heritability from decades of twin research, the profound impact of the microbiome on health and disease, and the effect of diet on the gut microbiome. Show Notes: 0:00 Intro to The Genetics Podcast 01:00 Welcome to Tim and his journey from clinical medicine to pioneering twin studies and uncovering the heritability of diseases and traits 07:47 Exploring missing heritability and why twin studies and GWAS offer different answers 11:40 What a global mega twin registry could reveal about epigenetics, environment, and disease 14:58 Findings from a twin microbiome study and how that evolved into a new chapter in Tim’s research career 18:29 The profound impact of the microbiome on health 23:31 Evolution in microbiome research techniques, microbe-diet associations, and the need for longitudinal studies 29:56 Potential reasons why fecal transplant did not turn out to be as effective as predicted 31:57 The importance of balance in the gut microbiome and how it can be involved in cancer and the drug response 39:41 Barriers to translating microbiome science into healthcare 42:57 The impact of microplastics and ultra-processed foods on the microbiome 46:13 Moving away from diversity measures for evaluating the microbiome and towards a more comprehensive score metric 49:42 Closing remarks with information on Tim’s upcoming book as well as Zoe products and app