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Two bottles in your medicine cabinet. Advil: $15 Generic ibuprofen: $5 FDA requires them to be IDENTICAL. Same active ingredient. Same dose. Same factory. But when you take Advil, it works better. 30% better pain relief. Why? Not the drug. Your brain. Today: The science of how price changes your biology. --- 🧒 THE ANSWER (Explained Like You're 5) You have a headache. Mom gives you two "magic candies." Blue: "This costs $1, it's okay." Red: "This costs $10, it's SUPER powerful!" You eat the red one. Headache gone! Why? Both were plain sugar. Your brain heard "$10 = super strong." Your brain believed it. Your brain released REAL pain-killing chemicals. Pain ACTUALLY went away. That's placebo effect. It works with REAL medicine too. --- ⏰ TIMESTAMPS 0:00 - The $15 vs $5 Paradox 0:30 - Magic Candy (ELI5) 1:00 - System 1: Price = Brain Chemistry 4:00 - System 2: Brand = Trust = Effect 6:30 - System 3: The Ritual Matters 8:30 - The Complete System 8:50 - What Should You Do? 9:20 - Test It Yourself Challenge --- 🎯 THE 3 SYSTEMS SYSTEM #1: PRICE CHANGES BIOLOGY Stanford Pain Study (2015): 82 people, mild electric shocks Two groups, both get placebo Group A: "This costs $2.50 per pill" Group B: "This costs $0.10 per pill" Results: Expensive: 85% pain reduction Cheap: 61% pain reduction 39% better from SAME SUGAR PILL. Brain scans showed: Prefrontal cortex activated (expectation) Endorphins released (natural painkillers) Pain signals actually decreased Not imagination. Real biochemistry. Mechanism: Price → Expectation → Brain releases chemicals → Real effect Real world application: FDA requirements for generics: Identical active ingredient (200mg ibuprofen) Same dosage Bioequivalent (absorbed same way) By law: Advil = Generic ibuprofen Prices: Advil: $15/100 Generic: $5/100 Consumer reports: 68% say Advil "works better" Willing to pay 3X more Why? Placebo by proxy. See "Advil" → Brain thinks "expensive = effective" → Higher expectation → Brain creates stronger effect Even more extreme: Parkinson's study (2015): Patients receiving deep brain stimulation Group A told: "Treatment costs $2,000" Group B told: "Treatment costs $200" SAME treatment. Same electrical pulses. Results: $2,000 group: Significant motor improvement $200 group: Less improvement Measured actual motor skills, not feelings. Price changed how brain responded to treatment. --- SYSTEM #2: BRAND = TRUST = EFFECT Energy drink study (Duke University, 2008): Participants solve puzzles Group A: Drink costs $2.50 Group B: Same drink "on sale" $0.89 Results: Expensive: 30% better performance Cheap: No improvement Same caffeine. Same sugar. Different price tag. Why brands work: Mechanism 1: Familiarity "Seen Advil ads my whole life" = "Must work" = Brain expects effect = Creates effect Mechanism 2: Social proof "Everyone uses Advil" = "Must be good" = Stronger expectation = Stronger effect Mechanism 3: Quality association "Expensive = quality" = "More effective" = Self-fulfilling prophecy Case study: Cough syrup Robitussin vs Generic Same ingredient: Dextromethorphan Same concentration Prices: Robitussin: $12 Generic: $4 Consumer experience: Brand: "Fast relief, cough stopped quickly" Generic: "Okay I guess, took a while" Blind tests: When people don't know which is which = NO DIFFERENCE When they know = Brand "works better" All placebo enhancement. Industry knows this: 2022: $6.58 billion on direct-to-consumer pharma ads Why? Not just awareness. Creating expectation. Expectation creates real medical effects. They're "buying" placebo effect. Worth $50B+/year extra sales. --- SYSTEM #3: RITUAL AMPLIFIES EFFECT Study: Injectable vs Pill placebo Same saltwater. Different delivery. Results: Injection: 40% more effective Pill: Baseline Why? Ritual is more "medical." Packaging study: Same pills. Different boxes. Brand packaging: Sleek, professional, "clinically tested" Generic packaging: Plain white, basic, minimal Results: Brand packaging 28% more effective Doctor effect: Doctor A: Confident - "This will make you feel much better" Doctor B: Uncertain - "Um, this might help, we'll see" Same medication. #Placebo #PlaceboEffect #Medicine #Generic #BrandName #Advil #Ibuprofen #ExplainedLikeIm5 #ELI5 #BrainScience #Neuroscience #FDA #PainRelief #Healthcare #MedicalScience #ConsumerPsychology #BehavioralEconomics #HiddenDecisions #SaveMoney #GenericDrugs #Pharmacology