Development of an ex vivo whole organ perfusion system for donor organ studies скачать в хорошем качестве

Development of an ex vivo whole organ perfusion system for donor organ studies

Presenter: Ian Rogers, PhD University of Toronto Dr. Rogers and his team are developing an ex vivo 3D organ culture system that supports native mouse and pig organs and can also be used to 'humanize' porcine organs that could be used for organ transplantation. To generate de novo donor organs for transplantation the porcine organ is decellularized, removing all of the porcine cells but leaves behind the protein frame (extracellular matrix-ECM). Then, they repopulate the acellular ECM with organ progenitor cells derived from patient induced pluripotent stem cells thus creating humanized organs. Both the native and humanized organs can also be used as disease models for drug and cell therapy development.