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On 29th January 2026, Dr. Archana Ramalingam, Scientist E at the ICMR – National Institute of Epidemiology, led an insightful PRISM Talks session on building essential skills to critically read and interpret published clinical trials. Through practical guidance and real-world examples, she unpacked key elements of study design, identification of bias, accurate interpretation of results, and assessment of clinical and public health relevance. The session equipped participants with tools to move beyond abstracts and confidently evaluate the quality and applicability of clinical research for evidence-based decision-making. A must-watch for researchers, clinicians, public health professionals, and anyone looking to strengthen their critical appraisal skills. Timestamp: | 00:00 -- Introduction | 01:44 – Introduction | 05:29 – Getting Started with Reading a Published Clinical Trial | 08:48 – Four Key Questions to Ask Before Reading a Paper | 10:27– What Needs to Be Looked at In-Depth in the Research Question | 20:44 – Randomisation with examples | 25:31 – Allocation Concealment | 30:25 – How to Reduce Bias in Trials | 34:39 – Completeness of Follow-up | 39:07 – Analysis of Trail Findings | 50:55 – Is the Sample Size Sufficient to Detect Power? | 55:44 – Summary of the Session | 58:18 – Interactive Q&A and Outro