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Subscribe: / @drtyna A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture. ___________________________________________________________________________________________ Social & Website: Instagram - / Website - https://www.drtyna.com/ Store - https://store.drtyna.com/ Courses - https://www.drtyna.com/store Metabolic Revamp Toolkit: https://bit.ly/drtynametabolicrevamp FREE GUIDE: Assess Your Metabolic Health: https://www.drtyna.com/metabolism GLP-1's Uncovered FREE 4 Part Video Series https://bit.ly/GLP1uncovered Subscribe to The Dr. Tyna Show: Apple Podcasts: https://apple.co/4bm3R3m Spotify: https://spoti.fi/3OtOps7 Substack: https://drtyna.substack.com/ ___________________________________________________________________________________________ On This Episode We Cover: 00:00:00 – Introduction 00:02:44 – Obesity study on GLP1s and weight loss 00:04:21 – Calories in vs. calories out 00:05:44 – Resting metabolic rate 00:09:25 – Metabolic adaptation during dieting 00:12:11 – Tirzepatide dosing in clinical studies 00:15:49 – Maintaining weight loss 00:18:15 – GLP1s & increased fat oxidation 00:19:14 – GLP1 microdosing myths 00:26:06 – Metabolic rate drops vs. metabolic improvements 00:29:51 – Lessons from the Biggest Loser study 00:34:20 – Study Comparation 00:35:25 – Weight loss, inflammation, and aging 00:36:35 – Health autonomy 00:40:23 – Caloric restriction and the CALERIE study ___________________________________________________________________________________________ Studies Mentioned: Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation https://pubmed.ncbi.nlm.nih.gov/40203... Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition https://pmc.ncbi.nlm.nih.gov/articles... Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) https://www.nia.nih.gov/research/reso... ___________________________________________________________________________________________ Show Links GLP-1s Done Right University https://www.drtyna.com/offers/VstUywX... Dr. Tyna’s Strength Corner https://www.drtyna.com/offers/jyTRpoF... Metabolic Revamp Toolkit + Masterclass https://www.drtyna.com/offers/FYvv4hJ... ___________________________________________________________________________________________ Further Listening: GLP1s Uncovered (Free Class) https://bit.ly/GLP1uncovered • EP. 202 | The Fight for Affordable GLP1s &... ___________________________________________________________________________________________ Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. #drtyna #podcast #thedrtynashow #metabolichealth #strengthtraining