Lec 23 Amines as Bases and Diazonium Chemistry скачать в хорошем качестве

Lec 23 Amines as Bases and Diazonium Chemistry

This is the 23rd lecture from the course Chem 51C Organic Chemistry taught by David Van Vranken at UC Irvine in Spring 2020. At the beginning of the lecture I talk about Bill Gates' experience in his organic chemistry course. I talk about the partitioning of amines between organic solvents and either unbuffered aqueous acid or unbuffered aqueous base and the chemistry of free-basing of cocaine. I introduce the non-basicity of amide nitrogens and the reduced basicity of anilines, particularly when resonance acceptors are ortho or para. I talk about the differential basicity of two types of nitrogens in aromatic heterocycles. Finally, I present the synthesis of arenediazonium ions from anilines and the subsequent substitution of diazonium ions with activated arenes, HO, F, I, and CN groups. Course Coverage: Organic Chemistry 5th Ed., J. Gorzynski-Smith Chapter 18: Electrophilic Aromatic Substitution Chapter 19: Carboxylic Acids and the Acidity of the O-H Bond Chapter 20: Introduction to Carbonyl Chemistry; Organometallic Reagents; Oxidation and Reduction Chapter 21: Aldehydes and Ketones--Nucleophilic Addition Chapter 22: Carboxylic Acids and Their Derivatives--Nucleophilic Acyl Substitution Chapter 23: Substitution Reactions of Carbonyl Compounds at the α Carbon Chapter 24: Carbonyl Condensation Reactions Chapter 25: Amines