3. Anti- Anginal Drugs: Nitrates (Part-3): CVS Pharmacology USMLE Step 1 скачать в хорошем качестве

3. Anti- Anginal Drugs: Nitrates (Part-3): CVS Pharmacology USMLE Step 1

📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash 3. Anti- Anginal Drugs: Nitrates (Part-3): CVS Pharmacology ------------------------------------------------------------------------------------------------- Nitrates remain a fundamental part of anti-anginal therapy, offering symptomatic relief by reducing myocardial oxygen demand and enhancing coronary perfusion 💓💊. These drugs, including nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate, act by releasing nitric oxide (NO), which stimulates guanylate cyclase, leading to increased cyclic GMP (cGMP) levels and smooth muscle relaxation in blood vessels 🧬🔬. This results in venodilation (reducing preload) and arterial dilation (reducing afterload), ultimately decreasing cardiac workload and oxygen demand 🩸💖. Sublingual nitroglycerin is used for acute angina attacks due to its rapid onset (1-5 min), while oral and transdermal nitrates are prescribed for long-term angina prophylaxis ⏳💥. However, prolonged use can lead to nitrate tolerance, where the body adapts, reducing the drug’s effectiveness. To counter this, a nitrate-free interval of 10-12 hours (usually overnight) is recommended ⏳⚠️. Adverse effects include headache (due to meningeal vasodilation), hypotension, dizziness, reflex tachycardia, and flushing, necessitating cautious dose adjustments 🚑💢. Nitrates are contraindicated with PDE-5 inhibitors (e.g., sildenafil, tadalafil) due to the risk of severe, life-threatening hypotension ⚠️🔴. Despite their benefits, nitrates do not alter the progression of coronary artery disease (CAD) and are used primarily for symptom relief, often in combination with beta-blockers or calcium channel blockers for optimal angina management 💉🏥. Patient education on proper dosing, avoiding abrupt discontinuation, and recognizing signs of hypotension is crucial for safe and effective use 🏥💡. With the rational use of nitrates, patients with ischemic heart disease can achieve better symptom control and improved quality of life 🌍❤️. #Nitrates #AntiAnginalDrugs #Cardiology #CVSPharmacology #Nitroglycerin #IsosorbideMononitrate #IsosorbideDinitrate #AnginaRelief #HeartHealth #MedicalScience #USMLE #NEETPG #Pharmacology #Vasodilation #MyocardialIschemia #RationalDrugUse #CoronaryArteryDisease #SaveHearts #GlobalHealth #CardiacCare #medicalanimations #fmge #fmgevideos #rapidrevisionfmge #fmge2024 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2025 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #usmlestep2videos