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The years 2024–2025 were some of the most financially challenging for organisations working on antimicrobial resistance (AMR). With major funders such as USAID and the Fleming Fund reducing support, critical AMR programmes faced uncertainty, downsizing, and difficult decisions. In this powerful final episode of 2025, Prof. Mirfin Mpundu reflects on: • How AMR organisations coped with severe funding cuts • Key lessons learned from navigating financial instability • What opportunities and threats lie ahead for AMR programmes in 2026 • What a fair, sustainable global and local funding landscape for AMR should look like • Whether increased domestic financing for AMR is realistic—and what it would take to make it work This episode is both a reflection on survival and a forward-looking conversation on sustainability, equity, and resilience in AMR financing.