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This video, made in collaboration with Dr. Zeynep Öztürk of the University of Oxford, explores the incredible role of model organisms in medical research, especially in cancer treatment and developmental biology. Given the growing importance of cancer research and treatment discovery, using different model organisms has never been more needed. This video highlights model organisms and their general use for cancer and developmental biology research, then discusses a practical application of a specific model organism, casper zebrafish, with an expert in the field, Dr. Zeynep Öztürk. This Video was made by McMaster University students Abdullah Al Azzawi, Menna Mohamed, Sarp Yilmaz, and Serena Radhi in collaboration with the Demystifying Medicine McMaster Program. This video is provided for general and educational information only. Please consult your healthcare provider for information about your health. Copyright McMaster University 2025 References: Adusumalli, R. (2021). Model organisms in cancer research-powers and limitations. Advances in Bioscience and Clinical Medicine, 9(2), 1. https://doi.org/10.7575/aiac.abcmed.v... Feitsma, H., & Cuppen, E. (2008). Zebrafish as a cancer model. Molecular Cancer Research, 6(5), 685–694. https://doi.org/10.1158/1541-7786.mcr... Gopal, U., Monroe, J. D., Marudamuthu, A. S., Begum, S., Walters, B. J., Stewart, R. A., Washington, C. W., Gibert, Y., & Zachariah, M. A. (2023). Development of a triple- negative breast cancer leptomeningeal disease model in zebrafish. Cells, 12(7), 995. https://doi.org/10.3390/cells12070995 White, R. M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C., Bourque, C., Dovey, M., Goessling, W., Burns, C. E., & Zon, L. I. (2008). Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell, 2(2), 183–189. https://doi.org/10.1016/j.stem.2007.1... Join this channel to get access to perks: / @demystifyingmedicinemcmaster Subscribe to the McMaster Demystifying Medicine YouTube channel: / demystifyingmedicine This video is provided for general and educational information only. Please consult your health care provider for Information about your health. This video was made by McMaster students in collaboration with the McMaster Demystifying Medicine Program