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Table of Contents: 00:08 - Miniaturizing the CPB Circuit 01:09 - “Making Neonatal CPB Better”The perfusionist’s perspective 01:50 - The “Pediatric Perfusionists” 03:35 - Unique Environment of Pediatric Perfusion 04:09 - U.S.A. Pediatric CPB Case Distribution 04:29 - Miniaturization 04:30 - U.S.A. Pediatric CPB Case Distribution 05:01 - Miniaturization 05:02 - The goal: Optimizing conditions and minimizing the negatives 06:18 - The Problem - A matter of proportions 07:53 - Motivation for circuit miniaturization 09:01 - Motivation for circuit miniaturization 09:59 - Motivation for circuit miniaturization 11:02 - Conventional approaches to miniaturization 11:18 - 13:10 - How can we reduce the priming volume? 13:13 - 13:28 - How can we reduce the priming volume? 14:39 - 15:01 - Decrease tubing diameters 15:29 - Reduction in Tubing Diameters 16:09 - Tubing flow ranges 17:01 - Venous Line 17:26 - How can we reduce the priming volume? 17:47 - Oxygenators are Smaller 18:31 - Arterial Line Filter 19:03 - Arterial Line FiltersDo you need them? 19:49 - Arterial Line Filters 19:54 - Arterial Line Filters are Smaller 20:07 - Blood Cardioplegia Systems 20:11 - Blood CPS are Smaller 20:42 - Next Generation 20:53 - Re-design the pump console 21:11 - “Second generation pump oxygenator” 21:28 - Safety issues in Miniaturization 22:53 - Reaction Time 22:56 - VAVD 23:12 - VAVD 23:13 - VAVD 23:25 - VAVD 23:45 - VAVD 24:10 - VAVD 24:36 - VAVD 25:08 - VAVD 25:43 - Decreasing Blood Requirements through Miniaturization 26:26 - 27:18 - The Duke mini-circuit 27:44 - Compared to standard console 27:59 - Mini circuit - small roller pumps 28:12 - 28:25 - Mini-circuit cardiopulmonary bypass with vacuum assisted venous drainage: feasibility of an asanguineous prime in the neonate 28:31 - Clinical Applications 28:48 - Barrier sheet 28:56 - 29:27 - Limits of Miniaturization 29:48 -