Genomics, Imaging and AI - Ewan Birney скачать в хорошем качестве

Genomics, Imaging and AI - Ewan Birney

January 10, 2023 - The National Human Genome Research Institute (NHGRI) hosts a seminar, "Genomics, Imaging and AI - three technologies that are changing biological research through to clinical practice." Over the last two decades, three major technologies have developed as the bedrock of how we understand living systems: genomics, including nucleic acid-based molecular biology readouts; imaging from near-atomic resolution to whole organism structures; and machine learning, including the large and non-linear architectures of Artificial Intelligence (AI). Dr. Ewan Birney provides a brief tour of this technology development, using examples from the European Molecular Biology Laboratory (EMBL) and touches on both fundamental biological discoveries and clinical applications. Lastly, he provides perspective for the future of these technologies with their impressive opportunities, the landscape of data and skills needed to actualize them and some potential pitfalls to avoid. Event Details: https://www.genome.gov/event/genomics... Chapters: 0:00 - Introduction (Eric Green) 4:35 - Opening Remarks (Ewan Birney) 5:39 - About the European Molecular Biology Laboratory (EMBL) 6:55 - Current challenge in life sciences 7:49 - Understanding biology: same approach since the 1960s! 9:29 - Successive technology innovation 13:09 - Axes of improvement 16:25 - What has this enabled? 18:43 - Scientific services: Imaging across scales 21:38 - Three examples of new imaging modalities 25:15 - AI / Machine Learning 27:09 - Deep Learning 28:41 - Key elements for AI 30:37 - "Labelling" deep learning 35:06 - AlphaFold: accelerating scientific discovery in protein folding 38:49 - Deep learning by alternative maths infrastructure 41:38 - Open, organised fundamental biomolecular data 43:21 - Data resources at EMBL-EBI 44:13 - Global BioData Coalition 45:13 - Secondary use of genomics and imaging from Healthcare 46:45 - Computing environments: hardware (GPUs) with optimised data access 48:14 - Global Alliance for Genomics and Health (GA4GH) 48:55 - GA4GH in a Global Learning Health System 49:17 - Evolving the workforce 53:35 - Example 1 basic research ; The Nuclear Pore 54:46 - Example 2 Clinical operations 58:47 - Examples of profound changes in outcome 1:00:49 - Questions and Answers