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This video is adapted from 10.3390/biology13090750 The factors that influence electrical potential across the cell membrane are important because they affect cellular properties that, in turn, allow tissues, organs, and whole organism to function; as such, it is important to understand them. The distribution and movement of certain ions (i.e., Na+, K+, Ca2+) determine this electrical potential as they move across the membrane through channels and transport processes, some of which are impeded by the presence of other ions. As a particularly apt example: free Ca2+ ions are known to block open Na+ channels. This study illustrated that raising the Ca2+ ion concentration on one side of the membrane led to a larger membrane potential, and this is suggested herein to be caused by blockage of a leaky Na+ channel. If more such channels are present in the membrane, the effects of altering Ca2+ concentration have less impact.